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Developing Therapies for Treatment-Resistant Prostate Cancer

Cedars-Sinai Cancer Investigators from Cedars-Sinai Cancer have identified an investigational therapeutic approach that could be effective against treatment-resistant prostate cancer. Results of their Phase II clinical trial have led to a larger, multicenter trial that will soon be underway. Read More

Cardiac Antigen Identified as Mechanism for Heart Complication With Immunotherapy-Related Myocarditis

Vanderbilt-Ingram Cancer Center Myocarditis can occur in cancer patients treated with immune checkpoint inhibitors. Although the adverse event is rare, the mortality rate is nearly 50 percent. Now, researchers from Vanderbilt-Ingram Cancer Center have identified the mechanism for the deadly heart inflammation. Read More

Researchers Receive NCI Grant to Increase Targeted Cancer Treatments to Rural Patients

The University of Kansas Cancer Center Shellie Ellis, PhD, has been awarded a $1.2 million R01 grant from the National Cancer Institute (NCI) to test an intervention she and her colleagues designed known as TEAMSPORT (Multi-TEAM Systems Framework Precision Oncology Reflex Testing). The goal is to create a standardized approach to the ordering of genomic tests and adapt it for use in community cancer centers. Read More

Nanotechnology Platform Enables Immune Conversion of Cancer Cells, Sensitizing Them to Immunotherapy

The University of Texas MD Anderson Cancer Center A team of researchers at The University of Texas MD Anderson Cancer Center has developed a nanotechnology platform that can change the way the immune system sees solid tumor cells, making them more receptive to immunotherapy. The preclinical findings suggest this adaptable immune conversion approach has the potential for broad application across many cancer types. Read More

Can Targeted Therapy for KRAS Mutations Double as Part of Immunotherapy?

Laura and Isaac Perlmutter Cancer Center at NYU Langone The recent development of drugs that can kill cancer cells with KRAS mutations has been a major breakthrough. But in nearly all patients, tumors eventually become resistant to these drugs, and they stop working. Two research teams have now developed a way to overcome this resistance that may enable KRAS-targeted drugs—and perhaps drugs that target other mutant cancer-causing proteins in cancer cells—to pull double duty as an immunot…
Cingam Joins UNM

Cingam Joins UNM

University of New Mexico Comprehensive Cancer Center Having completed his undergraduate and medical degrees in his native India before coming to the U.S., Shashank Cingam, MD, completed an internal medicine residency at Louisiana State University and then came to UNM Cancer Center in 2018 for a fellowship in hematology-oncology. Dr. Cingam recently joined the faculty at the UNM Comprehensive Cancer Center. Read More
Cancer Surgeon Scientist Joins Division of Surgical Oncology

Cancer Surgeon-Scientist Joins Division of Surgical Oncology

UK Markey Cancer Center The Division of Surgical Oncology is pleased to welcome Mautin Barry-Hundeyin, MD, to the UK College of Medicine Department of Surgery. Dr. Barry-Hundeyin joins the NCI-designated UK Markey Cancer Center as a surgical oncologist specializing in the management of hepatopancreatobiliary and gastrointestinal malignancies. Read More

Machine Learning Can Help Predict Patient Response to Cancer Immunotherapy

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University In a small study, researchers at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy have successfully trained a machine learning algorithm to predict, in hindsight, which patients with melanoma would respond to treatment and which would not respond. Read More

AI-Enabled Study Unravels the Mechanics of Aging and Disease Progression

Roswell Park Comprehensive Cancer Center Researchers from Roswell Park Comprehensive Cancer Center, in collaboration with Gero and Genome Protection Inc., recently published new work that demonstrates the power of artificial intelligence (AI) combined with analytical tools borrowed from the physics of complex systems to provide insights into the nature of aging, resilience, and future medical interventions for age-related diseases including cancer. Read More
Porpiglia Inducted Into Philadelphia Academy of Surgery

Porpiglia Inducted Into Philadelphia Academy of Surgery

Fox Chase Cancer Center, Temple Health Fox Chase Cancer Center’s Andrea Porpiglia, MD, MSc, FACS, was recently inducted as a fellow into the Philadelphia Academy of Surgery. Founded in 1879, the academy is the oldest continuously meeting surgical society in the United States. Read More
Attardi Receives Outstanding Investigator Award

Attardi Receives Outstanding Investigator Award

Stanford Cancer Institute Stanford Cancer Institute member Laura Attardi, PhD, received the National Cancer Institute Outstanding Investigator Award. Dr. Attardi's research will provide crucial new insight into how to modulate p53 pathways in therapeutic strategies for cancer. Read More

Catchment Area Research and Data Science Listserv Launched

December 1 marks the launch of AACI's Catchment Area Research and Data Science (CARDS) listserv. The goal of the new listserv is to build a supportive and collaborative community for those involved in cancer center data collection, analysis, and utilization. CARDS is for individuals from community outreach, biostatistics, cancer informatics and anywhere else in our cancer centers where this work is happening. Read More
CRI Digital Abstracts and Posters Book Available

CRI Digital Abstracts and Posters Book Available

The 14th Annual AACI CRI Meeting Abstracts and Posters Book is now available to AACI members. The digital book features 74 abstracts from 28 cancer centers submitted for presentation at the CRI meeting this past July – the first in-person CRI meeting since 2019. Abstract topics spanned several areas of clinical trial operations, including quality assurance, community outreach and engagement, and trial start-up and activation. Read More
Construction Expansion Approved for New Cancer Center Complex

Construction, Expansion Approved for New Cancer Center Complex

UK Markey Cancer Center The University of Kentucky Board of Trustees approved the initiation of the construction of the new UK HealthCare cancer and advanced ambulatory complex. It also approved an expansion of the original design for the facility. The revised financial scope of this project is $500 million. Read More
Sanchez Named to Head the UNM Comprehensive Cancer Center

Sanchez Named to Head the UNM Comprehensive Cancer Center

Yolanda Sanchez, PhD, has been named to head the UNM Comprehensive Cancer Center. Dr. Sanchez is currently associate director of basic sciences at Dartmouth Cancer Center. She will start in her new role on February 6, 2023, becoming the first Hispanic woman to lead a National Cancer Institute-Designated Comprehensive Cancer Center. Read More
Jensen Appointed to ACS CAN Board

Jensen Appointed to ACS CAN Board

The University of Kansas Cancer Center Roy Jensen, MD, vice chancellor and director of The University of Kansas Cancer Center, has been named to the national board of directors for the American Cancer Society Cancer Action Network (ACS CAN). Read More
Mesa to Lead Atrium Health Cancer Service Line

Mesa to Lead Atrium Health Cancer Service Line

Ruben A. Mesa, MD, FACP, has been named president and executive director of Atrium Health's cancer service line—which includes both Atrium Health Levine Cancer Institute and Atrium Health Wake Forest Baptist Comprehensive Cancer Center—and vice dean for cancer programs at Wake Forest University School of Medicine. A member of AACI's Board of Directors, Dr. Mesa currently serves as executive director of Mays Cancer Center at UT Health San Antonio MD Anderson and professor of medicine at UT Healt…

$12 Million Grant Launches Research Center to Study Obesity and Obesity-Related Disease

The University of Kansas Cancer Center Researchers from across the University of Kansas Medical Center have contributed significantly to the field of obesity research over the years. Now, the Kansas Center for Metabolism and Obesity Research, funded by the National Institutes of Health, will be dedicated to that work. Read More

Center for Amputation Reconstruction Launches Osseointegration Program With FDA-Approved Implant System

Laura and Isaac Perlmutter Cancer Center at NYU Langone NYU Langone Health has completed its first set of surgeries using the only U.S. Food and Drug Administration-approved implantable prosthetic for people with limb loss available in the greater New York City area. Read More
Approval Received to Build Myeloma Research Institute

Approval Received to Build Myeloma Research Institute

Sylvester Comprehensive Cancer Center, University of Miami Two years ago, when C. Ola Landgren, MD, PhD, joined Sylvester Comprehensive Cancer Center to lead the myeloma program, he told Director Stephen D. Nimer, MD, that his goal was to establish a "top three" U.S. myeloma program within five years. Read More
Sobol Appointed Associate Director for Basic Research

Sobol Appointed Associate Director for Basic Research

Legorreta Cancer Center at Brown University Robert W. Sobol, PhD, has been appointed associate director for basic research and co-leader of the Cancer Biology Program at the Legorreta Cancer Center at Brown University. He leads efforts toward continued growth of the basic science program and will serve as the co-leader of the Cancer Biology Program. Read More

$10.8 Million Initiative Unites Engineering, Health Researchers to Improve Cancer Treatments

The University of Arizona Cancer Center A University of Arizona project, with funding from the state's New Economy Initiative, creates humanlike cancer models and growth environments to help improve prevention, diagnosis, and treatment. Joann Sweasy, PhD, is director of the University of Arizona Cancer Center and a member of AACI's Board of Directors. Read More
Ellis Fischel Cancer Center Becomes AAC Is Newest Member

Ellis Fischel Cancer Center Becomes AACI's Newest Member

AACI is pleased to add Ellis Fischel Cancer Center to its membership roster. Directed by Gerhard Hildebrandt, MD, FACS, Ellis Fischel’s strategic imperative is to use research and innovation to create accessible, value-based, cancer care and prevention. With more than 200 cancer-focused researchers across four Missouri campuses, the center has launched an innovative plan to create a consortium partnership with another AACI member, Siteman Cancer Center. Read More

Liquid Biopsies Could Predict Survival Odds for Patients With Metastatic Cancer

University of Michigan Rogel Cancer Center As cancers grow and potentially spread to new parts of the body, they often shed cells and DNA into the blood stream. DNA can be analyzed for both the amount of DNA present and whether any potential mutations exist that may aid providers in deciding on treatments. Read More
Family History Gene Variants Put Black Men at Risk for Early Prostate Cancer

Family History, Gene Variants Put Black Men at Risk for Early Prostate Cancer

Duke Cancer Institute, Duke University Medical Center A family history of cancer and genetic variants that might be inherited appear to be important risk factors for Black men diagnosed with early-onset prostate cancer, a study involving Duke Health researchers has found. Kathleen Cooney, MD, chair of the Duke Department of Medicine, is senior author of the study. Read More
Call for Abstracts 15th Annual AACI CRI Meeting

Call for Abstracts: 15th Annual AACI CRI Meeting

The AACI CRI Steering Committee is currently soliciting abstracts for the 15th Annual AACI CRI Meeting. This year’s meeting theme will focus on taking innovations in cancer clinical research from abstract to reality. The purpose of the abstracts is to inform meeting attendees about clinical trials office challenges and solutions implemented at AACI cancer centers. Read More

New Approach to Managing Post-Surgery Pain Reduces Opioid-Based Medication Use by 50 Percent

The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute and The Ohio State University Wexner Medical Center have implemented a radically different approach to post-surgery pain management that is focused on maximizing non-opioid techniques first, using opioids only as a back-up option. Read More

Cooling Glioblastoma to Room Temperature Extends Survival in Preclinical Study

Winship Cancer Institute of Emory University A new preclinical study, led by researchers currently at Emory University and UT Southwestern who began the work while they were at Duke University, suggests that cooling brain tumors to room temperature may extend survival of patients with glioblastoma multiforme. Read More
Hitchcock Appointed Vice Chair of National DEI Committee

Hitchcock Appointed Vice Chair of National DEI Committee

University of Florida Health Cancer Center Kate Hitchcock, MD, PhD, assistant professor in the Department of Radiation Oncology in the University of Florida College of Medicine, has been appointed vice chair of the Diversity, Equity and Inclusion (DEI) Committee of NRG Oncology, a nonprofit research organization. Read More

Study Finds Inherited Link to Appendix Cancer

Vanderbilt-Ingram Cancer Center One of every 10 patients with appendiceal cancer carries a germline genetic variant associated with cancer predisposition, according to a new study that is the first to show inherited risk factors for this rare cancer. The findings suggest all patients with appendix cancer should consider genetic evaluation as well as cascade testing and genetic counseling of at-risk family members. Read More

Personalized Immune Therapy Extended Survival in Patients With Aggressive Brain Cancer

Wilmot Cancer Institute, UR Medicine A Phase III clinical trial of the DCVax®-L cancer vaccine, conducted at the Wilmot Cancer Institute and other centers internationally, has shown that the vaccine extended survival in patients with newly diagnosed and recurrent glioblastoma brain cancer. Read More

Killing Pancreatic Cancer With T Cells That Supercharge Themselves

UCSF Helen Diller Family Comprehensive Cancer Center Scientists at UC San Francisco (UCSF) have engineered T cells to produce a potent anti-cancer cytokine, but only when they encounter tumor cells. The immunotherapy eliminated melanoma and pancreatic cancer in mice without major side effects, and it offers a promising new strategy for fighting these and other hard-to-treat cancers. Read More

Clues Found Regarding Tumor Suppressor Gene Breast Cancer Activity

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University Researchers at the Johns Hopkins Kimmel Cancer Center have revealed how the gene HOXA5 may work to suppress formation of breast cancers. A new study indicates that it binds to another protein in an inflammatory cell pathway, boosting that protein’s cancer-suppressing properties. Read More
Lee Named Director of Radiation Oncology

Lee Named Director of Radiation Oncology

University of New Mexico Comprehensive Cancer Center David Y. Lee, MD, PhD, has been named director of radiation oncology at the UNM Comprehensive Cancer Center. He joined UNM in September 2012 and assumed his new role on December 1, 2022. Read More
Hajiran Named Chief of Urologic Oncology

Hajiran Named Chief of Urologic Oncology

WVU Cancer Institute West Virginia University Medicine is proud to announce the appointment of Ali Hajiran, MD, as the new chief of Urologic Oncology. He specializes in treating complex cases of kidney, bladder, prostate, and testicular cancers using minimally-invasive robotic and traditional surgical techniques. Read More
Fatatis Appointed Associate Director for Basic Research

Fatatis Appointed Associate Director for Basic Research

Sidney Kimmel Cancer Center at Jefferson Health Alessandro Fatatis, MD, PhD, has been named associate director for basic research at Jefferson Health’s Sidney Kimmel Cancer Center (SKCC). Dr. Fatatis previously served as co-leader for SKCC’s Translational and Cellular Oncology Research Program. Read More
Improving Bladder Cancer Trials and Treatments Goal of New 6 Million CPRIT Recruit

Improving Bladder Cancer Trials and Treatments Goal of New $6 Million CPRIT Recruit

Houston Methodist Dr. Mary and Ron Neal Cancer Center With a focus on expediting the development of early-phase clinical trials and enhancing chemoimmunotherapy responses in bladder cancer, genitourinary cancer translational scientist Keith Syson Chan, PhD, is joining Houston Methodist thanks to a $6 million established investigator recruitment grant from the Cancer Prevention and Research Institute of Texas (CPRIT). Read More
Clinicians Named to List of Worlds Most Highly Cited Researchers

Clinicians Named to List of World's Most Highly Cited Researchers

Fox Chase Cancer Center, Temple Health Fox Chase Cancer Center physicians Hossein Borghaei, DO, MS, and Elizabeth Plimack, MD, MS, have been named to the 2022 list of Highly Cited Researchers by Clarivate, an information and analytics firm focused on research. Read More

Study: Hodgkin Lymphoma Survivors Show Signs of Dementia in Early Adulthood

Wilmot Cancer Institute, UR Medicine In a new study, the majority of individuals treated as children for Hodgkin lymphoma who are now in their 30s, showed signs of being an average of 7.7 years older biologically than their peers, placing them at risk for cognitive problems. Read More

Study Shows Menthol Cigarette Alternatives Pose Significant Addiction and Health Risks

The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute In a new study, scientists from the Center for Tobacco Research at The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute and Rutgers University studied 98 menthol cigarette smokers to examine the addiction potential of combustible menthol alternatives compared with traditional menthol cigarettes. Read More

Women With Elevated Breast Cancer Risk Could See Mortality Benefit From Estrogen-Blocking Drugs

Georgetown Lombardi Comprehensive Cancer Center While it has long been recognized that drugs that block the cancer-promoting activity of estrogen reduce the risk of developing new breast cancers, a new computer modeling study led by researchers at Georgetown Lombardi Comprehensive Cancer Center and colleagues showed that these treatments could also reduce the risk of dying from the disease in women who are at high risk. Read More

P53 Could Be Key to Therapies for Salivary Gland Cancer

University of Michigan Rogel Cancer Center Researchers at the University of Michigan Rogel Cancer Center and School of Dentistry found that certain drugs can change the fundamental makeup of cancer stem cells in mouse models of mucoepidermoid carcinoma. Read More

Experimental Cancer Therapy Shows Success in More Than 70 Percent of Patients in Global Clinical Trials

The Tisch Cancer Institute at Mount Sinai A new therapy that makes the immune system kill bone marrow cancer cells was successful in as many as 73 percent of patients in two clinical trials, according to researchers from The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. Read More
Wolmark Recognized for Scientific Distinction

Wolmark Recognized for Scientific Distinction

UPMC Hillman Cancer Center Norman Wolmark, MD, received the 2022 Susan G. Komen Brinker Award for Scientific Distinction at the recent San Antonio Breast Cancer Symposium (SABCS). Dr. Wolmark, chair of the NSABP Foundation and chair and principal investigator of NRG Oncology, delivered his address, "The Contribution of NSABP Clinical Trials to the Management of Early Breast Cancer: PAST AS PROLOGUE," on December 9 at SABCS. Read More

National Accreditation for Multidisciplinary High-Quality Care Renewed

University of Florida Health Cancer Center The UF Health Cancer Center has received a three-year reaccreditation from the Commission on Cancer, or CoC, a quality program of the American College of Surgeons, in recognition of its commitment to providing high-quality, patient-centered cancer care. Read More

Gersbach Elected Fellow of the National Academy of Inventors

Duke Cancer Institute, Duke University Medical Center Charles Gersbach, PhD, associate professor of surgery, orthopedic surgery, and cell biology, and Duke Cancer Institute member, has been elected Fellow of the National Academy of Inventors Class of 2022. Read More
Flowers Receives ASH Mentor Award

Flowers Receives ASH Mentor Award

The University of Texas MD Anderson Cancer Center Christopher Flowers, MD, division head ad interim of cancer medicine and chair of Lymphoma and Myeloma at The University of Texas MD Anderson Cancer Center, has received a 2022 ASH Mentor Award from the American Society of Hematology in acknowledgment of his career-long commitment to mentoring. Read More
Bhardwaj Honored With ESMO Award

Bhardwaj Honored With ESMO Award

The Tisch Cancer Institute at Mount Sinai Nina Bhardwaj, MD, PhD, was honored with the 2022 ESMO Award for Immuno-Oncology from the European Society for Medical Oncology in recognition of her outstanding contributions to cancer immunology research. Dr. Bhardwaj delivered her award lecture on December 7 during the ESMO Immuno-Oncology Congress 2022. Read More

Researchers Generate Lab-Grown Human Tissue Model for Food Tube Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University Researchers at Johns Hopkins Medicine say they have created a laboratory-grown three-dimensional "organoid" model that is derived from human tissue and designed to advance understanding about how early stages of cancer develop at the gastroesophageal junction. Read More
Associate Director of Translational Oncology Appointed

Associate Director of Translational Oncology Appointed

Legorreta Cancer Center at Brown University Sendurai A. Mani, PhD, has been appointed associate director for translational oncology at the Legorreta Cancer Center at Brown University and professor of pathology and laboratory medicine, effective December 1, 2022. Read More

AACI Applauds Passage of FY 2023 Omnibus Spending Package

Top congressional appropriators came to an agreement on a $1.7 trillion omnibus spending package for Fiscal Year (FY) 2023. The budget was passed and signed by President Biden ahead of the December 23 deadline. The agreement framework from the House and Senate Appropriations Committees on the omnibus includes funding numbers that fall short of AACI’s requests. However, the final budget numbers still represent significant increases for both the National Institutes of Health (NIH) and National Ca…

Study Finds Black Women Have Worst HR+/HER2- Breast Cancer Outcomes of All Racial and Ethnic Groups

Winship Cancer Institute of Emory University A large global clinical trial has found that non-Hispanic Black women with Hormone Receptor positive/HER2-negative breast cancer, with 1-3 involved lymph nodes and recurrence scores below 25, have worse outcomes than non-Hispanic white women with similar diagnosis. Read More

Novel Drug Combinations and Targeted Therapies Show Promise for Patients With Leukemia

The University of Texas MD Anderson Cancer Center Researchers from The University of Texas MD Anderson Cancer Center have presented findings from three clinical trials that highlight results to advance the use of targeted therapies and novel combinations in multiple types of leukemia, including high-risk and newly diagnosed acute myeloid leukemia in older and younger patients and Philadelphia chromosome-positive acute lymphoblastic leukemia. Read More

Accelerating Innovations in Early-Phase Oncology Trials

Laura and Isaac Perlmutter Cancer Center at NYU Langone Over the past 30 years there has been a considerable effort to improve early-phase oncology trials. One such effort is the Experimental Therapeutics Clinical Trials Network, a partnership program sponsored by the National Cancer Institute–Cancer Therapy Evaluation Program to evaluate early-phase trials in high-priority areas of unmet need through collaboration with a dozen Lead Academic Organizations. Read More

Myocarditis in Cancer Patients is Driven by Specific Immune Cells

UCSF Helen Diller Family Comprehensive Cancer Center In a new study, researchers from UC San Francisco and Vanderbilt University Medical Center have identified specific immune cells that drive deadly heart inflammation in a small fraction of patients treated with powerful cancer immunotherapy drugs. They also identified the heart muscle cells that are targeted by the destructive immune cells. Read More
Owusu Assumes Diversity Equity and Inclusion Role

Owusu Assumes Diversity, Equity, and Inclusion Role

Case Comprehensive Cancer Center Cynthia Owusu, MD, is the new associate director for diversity, equity, and inclusion for the Case Comprehensive Cancer Center. She is the principal investigator on a $2.8 million research grant awarded by the National Institute on Minority Health and Disparities. Read More
Researcher Receives Grant to Study Synthetic Targets for Tumor Drug Delivery

Researcher Receives Grant to Study Synthetic Targets for Tumor Drug Delivery

Fox Chase Cancer Center, Temple Health Swayam Prabha, MBA, PhD, a member of the Cancer Signaling and Microenvironment research program at Fox Chase Cancer Center, was recently awarded a $792,000 American Cancer Society research scholar grant to investigate new methods for treating lung cancer. Read More
Lovly Receives Lung Cancer Award

Lovly Receives Lung Cancer Award

Vanderbilt-Ingram Cancer Center The GO2 Foundation for Lung Cancer has recognized Christine Lovly, MD, PhD, with the 2022 Asclepios Award. The foundation recognized Dr. Lovly for her work on understanding and developing improved therapeutic strategies for specific clinically relevant molecular subsets of lung cancer, with a focus on mechanisms of sensitivity and resistance to agents used in clinical practice. Read More
Cullen to Retire as Director

Cullen to Retire as Director

University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center Kevin J. Cullen, MD, the longtime director of the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC), will transition from this position in 2023. Dr. Cullen has overseen four applications for National Cancer Institute designation at UMGCCC and a fifth as interim director of the Georgetown Lombardi Comprehensive Cancer Center. Read More

Cancer Center Receives Landmark $43 Million Federal Investment

The University of Kansas Cancer Center The University of Kansas Cancer Center was awarded $43 million through the federal spending bill, which President Joe Biden signed into law in December 2022. The allocation will help the cancer center plan and build a 670,000-square-foot research facility at the University of Kansas Medical Center campus. Kansas U.S. Senator Jerry Moran, who serves on the Appropriations Subcommittee on Commerce, Justice and Science and the Appropriations Subcommitte…
Schwartz Named New Director at Case Comprehensive Cancer Center

Schwartz Named New Director at Case Comprehensive Cancer Center

Gary Schwartz, MD, will become director of the Case Comprehensive Cancer Center this spring, succeeding Stanton L. Gerson, MD, a past AACI president, who has led the center since 2004. Dr. Schwartz is chief of the Hematology & Oncology Division at Columbia University Irving Medical Center and deputy director of its Herbert Irving Comprehensive Cancer Center. Read More
Uzzo Presents Rhoads Oration for Philadelphia Academy of Surgery

Uzzo Presents Rhoads Oration for Philadelphia Academy of Surgery

Fox Chase Cancer Center, Temple Health Joining more than 100 previous orators, Robert Uzzo, MD, MBA, FACS, president and CEO of Fox Chase Cancer Center, delivered the Rhoads Oration for the Philadelphia Academy of Surgery at The College of Physicians of Philadelphia. His oration discussed the origins of kidney cancer, as well as environmental and tissue-specific responses that may affect its development. Read More

Study: Chronic Opioid Use Reduced by Limiting Prescribed Opioids After Surgery

Roswell Park Comprehensive Cancer Center Research at Roswell Park Comprehensive Cancer Center shows that putting a three-day limit on opioid prescriptions to treat surgical pain after hospital discharge reduces the number of patients who become chronic opioid users without compromising pain relief or recovery. It also reduces the amount of opioids circulating in the community. Read More
Sotorasib Shows Meaningful Anticancer Activity in KRAS G12 C mutated Metastatic Pancreatic Cancer

Sotorasib Shows Meaningful Anticancer Activity in KRAS G12C-mutated Metastatic Pancreatic Cancer

University of Florida Health Cancer Center UF Health was a study location for a multicenter Phase I-II trial showing that the KRAS G12C inhibitor sotorasib achieved anticancer activity with an acceptable safety profile in heavily pretreated patients within KRAS G12C-mutated metastatic pancreatic cancer. Thomas George, MD, FACP, was a coauthor on the study. Read More

Streamlining Lung Cancer Screening

Cedars-Sinai Cancer Cedars-Sinai Cancer is taking on the country’s leading cause of cancer-related death with a new lung cancer screening program designed to reach more patients, simplify the screening process, and provide fast access to follow-up care. Read More
Weissman Receives Award for Lifetime Achievement in Hematology

Weissman Receives Award for Lifetime Achievement in Hematology

Stanford Cancer Institute Irv Weissman, MD, was presented with the American Society of Hematology’s (ASH) highest honor, the 2022 Wallace H. Coulter Award for Lifetime Achievement in Hematology. He is the former director of Stanford's Institute for Stem Cell Biology and Regenerative Medicine. Read More
Gadi Named Deputy Director

Gadi Named Deputy Director

University of Illinois Cancer Center VK Gadi, MD, PhD, whose laboratory and clinical research has focused primarily on breast cancer, is the new deputy director of the University of Illinois Cancer Center. Dr. Gadi joined the cancer center in March 2020 as associate director of translational medicine. Read More

Diversity in Clinical Trials Award Program to Expand

The Robert A. Winn Diversity in Clinical Trials Award Program established by the Bristol Myers Squibb Foundation announced that Amgen, a global biotechnology company, has committed to contribute $8 million over the next four years. Dr. Winn is AACI Vice President/President-elect, and Bristol Myers Squibb and Amgen are AACI Corporate Roundtable members.   Read More
AACI Welcomes LSU LCMC Health Cancer Center

AACI Welcomes LSU-LCMC Health Cancer Center

In January the Louisiana State University-Louisiana Children’s Medical Center (LSU-LCMC) Health Cancer Center became the 108th member of AACI. Professor of Surgery and Interdisciplinary Oncology John H. Stewart, IV, MD, MBA, is the founding director of the cancer center, which was established in 2021. Read More

CRI Abstract Submission Tool Now Open

Abstract submissions are now being accepted for the 15th Annual AACI CRI Meeting, June 26-28, 2023, at the Loews Chicago O'Hare Hotel in Rosemont, IL. This year’s meeting theme will focus on taking innovations in cancer clinical research from abstract to reality. Completed abstracts are due by 5:00 pm Pacific time on Monday, March 13. Read More
Lamba Receives 3 3 Million Grant for Pediatric AML Research

Lamba Receives $3.3 Million Grant for Pediatric AML Research

University of Florida Health Cancer Center Jatinder Lamba, PhD, a professor in the department of pharmacotherapy and translational research in the University of Florida College of Pharmacy, has received a $3.3 million five-year R01 grant from the National Cancer Institute to study the biology of acute myeloid leukemia, or AML. Read More
Wargo Recognized for Microbiome Research

Wargo Recognized for Microbiome Research

The University of Texas MD Anderson Cancer Center Jennifer Wargo, MD, has received a 2023 Edith and Peter O’Donnell Award in Medicine from the Texas Academy of Medicine, Engineering, Science and Technology (TAMEST) for her contributions to the understanding of how the gut microbiome influences responses to immunotherapy and other cancer treatments. Read More

Using a Seaweed Sugar to Trigger Immune Responses That Suppress Melanomas

Moffitt Cancer Center Moffitt Cancer Center researchers have identified a relatively natural way to increase the numbers and antitumor activities of tumor-infiltrating lymphocytes (TILs). A new study demonstrates how L-fucose, a nontoxic dietary plant sugar that is enriched in red and brown seaweeds, can increase TILs, promote antitumor immunity and improve the efficacy of immunotherapy. Read More

Researchers Circumvent Radiation Resistance in Subtype of Brain Tumors

University of Michigan Rogel Cancer Center Patients whose brain tumors have a mutated enzyme called IDH1 typically live longer than those without the mutation. But even as these tumors are initially less aggressive, they always come back. A key reason: the tumors are resistant to radiation treatment and are invasive. Researchers at the University of Michigan Rogel Cancer Center have uncovered a gene that is overexpressed in mutated IDH1. The gene, called ZMYND8, plays a critical role in …
Metastasis Markers

Metastasis Markers

University of New Mexico Comprehensive Cancer Center In a new paper, Dario Marchetti, PhD, and his team at the UNM Comprehensive Cancer Center describe the process they used to identify the genetic signs of melanoma that is likely to spread. They isolated circulating tumor cells from people with melanoma who represented a range of stages and created and used mouse models to find the signature for metastasizing melanoma. Read More
Kelly Appointed Chair of Medical Oncology

Kelly Appointed Chair of Medical Oncology

Sidney Kimmel Cancer Center at Jefferson Health Wm. Kevin Kelly, DO, has been appointed chair of the Department of Medical Oncology for the Sidney Kimmel Medical College at Thomas Jefferson University. An expert in genitourinary cancers and drug development for prostate cancer and other malignancies, Dr. Kelly joined Jefferson in 2010 and currently serves as associate director of clinical research in the Sidney Kimmel Cancer Center. Read More

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Moffitt Breaks Ground on New Campus

Moffitt Breaks Ground on New Campus

Moffitt Cancer Center A January groundbreaking and naming celebration for "Speros FL" officially kicked off construction of the 775-acre Pasco County, FL campus featuring 16 million square feet of lab, office, manufacturing and clinical space. The name, Speros, is a derivative of the Latin verb "Sperare," meaning "to hope" or "to look forward to." Read More

Aggressive Surgery Increases Survival With Low-Grade Brain Tumors

UCSF Helen Diller Family Comprehensive Cancer Center The transition of a low-grade, slow growing brain tumor to a lethal one can be delayed if neurosurgeons remove as much as possible soon after diagnosis, according to the results of a study led by UC San Francisco. The findings run counter to other research indicating that extensive resection, or maximal surgical removal, may not be necessary depending on tumor characteristics. Read More
Rogers Appointed Associate Cancer Center Director for DEI

Rogers Appointed Associate Cancer Center Director for DEI

Yale Cancer Center, Yale School of Medicine Faye Rogers, PhD, associate professor of therapeutic radiology, has been appointed associate cancer center director for diversity, equity, and inclusion (DEI) at Yale Cancer Center. She will lead the center’s efforts to enhance its culture of belonging, including programs and training in cultural and structural humility, counteracting stigma and stereotypes, and gender discrimination. Read More
Researcher Receives Asbestos Disease Awareness Award

Researcher Receives Asbestos Disease Awareness Award

The Tisch Cancer Institute at Mount Sinai Andrea Wolf, MD, director of the New York Mesothelioma Program at the Mount Sinai Health System, has received the 2022 Irving J. Selikoff Lifetime Achievement Award from the Asbestos Disease Awareness Organization. Read More
Ermann Selected as Mentoring Program Scholar

Ermann Selected as Mentoring Program Scholar

Huntsman Cancer Institute at the University of Utah Daniel Ermann, MD, hematology and oncology fellow at Huntsman Cancer Institute, has been selected as a scholar for the 2023 Lymphoma Scientific Research Mentoring Program by the Lymphoma Research Foundation. As a scholar, Dr. Ermann will receive a $10,000 career development help with his current clinical trial and develop skills to apply for grants for future studies. Read More

Updated Online Tool First to Assess Risk of Cancer, Heart Disease Using Family Data

The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute A cutting-edge upgrade of an online tool developed by genetic experts and data scientists at The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute and The Ohio State University Wexner Medical Center is the first to fully assess an individual’s hereditary risk for cancer or heart disease using personal and family health history. …
Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma

Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma

Stanford Cancer Institute Stanford Cancer Institute member Jiangbin Ye, PhD, and colleagues found that mitochondrial uncoupling is an effective metabolic and epigenetic therapy for reversing the Warburg Effect and inducing differentiation in neuroblastoma. Read More

After 10 Years and One Thousand Studies, Epigeneticists Uncover Trouble in Their Toolbox

Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine In a new study, a team led by researchers at Baylor College of Medicine reveals that the commercial tool that has been the workhorse for epigenome-wide association studies is actually not appropriate for population epigenetics. Read More
Holzbeierlein Appointed Physician in Chief

Holzbeierlein Appointed Physician in Chief

The University of Kansas Cancer Center Jeffrey Holzbeierlein, MD, was named physician in chief of The University of Kansas Cancer Center. He will assume the role held by Terry Tsue, MD, who retired in January after serving in the health system appointed position for the past 10 years. Read More
Cognitive Behavioral Therapy Appears Promising for Head and Neck Cancer Survivors

Cognitive Behavioral Therapy Appears Promising for Head and Neck Cancer Survivors

Hollings Cancer Center, Medical University of South Carolina An MUSC Hollings Cancer Center team, led Evan Graboyes, MD, published results of a pilot trial evaluating a tele-cognitive behavioral therapy for head and neck cancer survivors who have developed clinically significant body-image distress. Now, with a $3.2 million grant from the National Cancer Institute, the team is preparing to enroll patients in a larger, multi-institution trial. Read More
Winkfield Named to ACS CAN National Board of Directors

Winkfield Named to ACS CAN National Board of Directors

Vanderbilt-Ingram Cancer Center Karen Winkfield, MD, PhD, executive director of the Meharry-Vanderbilt Alliance, has been named one of three new members of the American Cancer Society Cancer Action Network’s national board of directors. Dr. Winkfield is a professor of radiation oncology at Vanderbilt-Ingram Cancer Center, and professor of Medicine at Meharry Medical College. Read More

Foundation Gifts Create Cancer Informatics Chair

Indiana University Melvin and Bren Simon Comprehensive Cancer Center Gifts totaling $3 million will create an endowed chair in cancer informatics at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center. The chair was created through gifts from the Walther Cancer Foundation Inc. and the Regenstrief Foundation Inc. The jointly recruited chair holder will be a research scientist at the Regenstrief Institute and cancer center and a faculty member at Indiana University. …

Champion for Cures Nominations Due March 31

AACI cancer center directors are invited to submit nominations for the 2023 Champion for Cures Award. The submission deadline is Friday, March 31. The Champion for Cures Award will be presented during the 2023 AACI/CCAF Annual Meeting, October 1-3, at the Salamander Washington DC. Read More

Taming Overactive mTOR in Renal Cell Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University In a new study from the Johns Hopkins Kimmel Cancer Center, researchers described a novel mechanism of tumor formation in kidney cancers driven by overexpression of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway with loss of the tuberous sclerosis complex tumor suppressor gene. Their findings point to potential therapeutic targets for some of the most aggressive renal cell cancers. R…

Researchers Uncover New Pathway for Molecular Cancer Drug Therapies

UCSF Helen Diller Family Comprehensive Cancer Center In a study published in Science, Kevin Lou, an MD-PhD student, Luke Gilbert, PhD, and Kevan Shokat, PhD, revealed the discovery of a cellular uptake pathway important for larger molecules. These large and complex molecules bind in unconventional ways to their targets, are efficiently taken up by target cells, and can be harnessed to create new drugs for the treatment of cancer and other diseases. Read More
Cancer Center Gets 1 1 Million Gift for Holistic Cancer Care

Cancer Center Gets $1.1 Million Gift for Holistic Cancer Care

The University of Arizona Cancer Center A $1.1 million gift will support the development of a University of Arizona Cancer Center program that aims to integrate traditional medicine and therapies with Western cancer treatments to improve health outcomes and encourage patient well-being. Jennifer Hatcher, PhD, MPH, RN, is the center's associate director of cancer community outreach and engagement. Read More

Study Shows How Liver Cancer Hijacks Circadian Clock Machinery Inside Cells

USC Norris Comprehensive Cancer Center A study led by researchers at the Keck School of Medicine of USC not only directly links circadian clock proteins to liver cancer, but also shows precisely how cancer cells hijack circadian clock machinery to divide and spread. The research, also found that inhibiting key clock proteins can prevent cancer cells from multiplying. Read More

Study Finds New Genetic Risk Factors for Colorectal Cancer, Paving the Way For Better Screening, Prevention

Fred Hutchinson Cancer Center A comprehensive analysis of more than 100,000 colorectal cancer cases, led by researchers at the Fred Hutchinson Cancer Center and 200 scientific collaborators worldwide, has identified more than 100 new genetic risk factors strongly linked with the disease. Read More

Luck Favors the Prepared Mind

Duke Cancer Institute, Duke University Medical Center Two promising metastatic breast cancer drug discoveries have emerged from the McDonnell Lab at Duke into the clinic. One of the drugs, Elacestrant, was approved by the FDA on January 27 to treat certain postmenopausal women or adult men with advanced or metastatic ER-positive, HER2-negative, ESR1-mutated breast cancer after one or more lines of endocrine therapy. Read More

Study Suggests a Way To Re-Energize Tired T Cells When Treating Cancer, Viral Infections

The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute A new study by researchers at OSUCCC – James suggests a way to re-energize critical killer immune cells that have become exhausted when fighting cancer or chronic viral infections. Read More

Study Addresses Colorectal Cancer Disparities in Black Communities

UK Markey Cancer Center A new UK Markey Cancer Center study highlights the need for increased outreach and education to reduce colorectal cancer screening disparities in Black communities. According to the qualitative study, people in Kentucky’s Black communities may not be aware about all of the colorectal cancer screening options available to them, particularly stool-based tests. Read More